"Deprive a cell 35% of its oxygen for 48 hours and it may become cancerous." -Otto Warburg
"... all normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose." -Otto Warburg
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Dr. Otto Warburg defined Cancer almost fifty years ago. And yet today, the consensus of current researchers is that cancer is a complete mystery!
His paper, "The Prime Cause and Prevention of Cancer" was the first Nobel Prize in Medicine awarded him that he could collect. The original one he could not collect, he lived in Nazi Germany at the time and was a Jew.
Only one other man, Linus Pauling, has been awarded two Nobel Prizes, and even Pauling was not awarded both in his primary field, while Warburg was.
As Warburg declares, there are many secondary causes of cancer(environmental, ionizing radiation, chemicals), there still remains but one primary cause, a self sustaining metabolic dysfunction of tissue that deprives the cells of oxygen.
When a cell is oxygen deprived the metabolic pathway of respiration is diverted to an alternate pathway without oxygen called anaerobic metabolism. Warburg called this fermentation. This is an extremely inefficient use of cellular fuel that is also very dirty, and toxic (pyruvate is a neuro-toxin).
For every molecule of glucose thirty eight molecules of ATP is created in the aerobic pathway, but only about two are created in the non-aerobic pathway, and both lactic acid and pyruvate accumulate in and surrounding the cell as a result.
"... all normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose." -Otto Warburg
...
Dr. Otto Warburg defined Cancer almost fifty years ago. And yet today, the consensus of current researchers is that cancer is a complete mystery!
His paper, "The Prime Cause and Prevention of Cancer" was the first Nobel Prize in Medicine awarded him that he could collect. The original one he could not collect, he lived in Nazi Germany at the time and was a Jew.
Only one other man, Linus Pauling, has been awarded two Nobel Prizes, and even Pauling was not awarded both in his primary field, while Warburg was.
As Warburg declares, there are many secondary causes of cancer(environmental, ionizing radiation, chemicals), there still remains but one primary cause, a self sustaining metabolic dysfunction of tissue that deprives the cells of oxygen.
When a cell is oxygen deprived the metabolic pathway of respiration is diverted to an alternate pathway without oxygen called anaerobic metabolism. Warburg called this fermentation. This is an extremely inefficient use of cellular fuel that is also very dirty, and toxic (pyruvate is a neuro-toxin).
For every molecule of glucose thirty eight molecules of ATP is created in the aerobic pathway, but only about two are created in the non-aerobic pathway, and both lactic acid and pyruvate accumulate in and surrounding the cell as a result.